Dydrogesterone: What It Does and How to Use It Safely

Want a straight answer about dydrogesterone? It’s an oral progestin often sold as Duphaston and used for menstrual problems, luteal phase support, and some cases of threatened miscarriage. It’s a synthetic form of the hormone progesterone that acts like the natural one but is taken by mouth.

How dydrogesterone works and common uses

Dydrogesterone works by supporting the lining of the uterus and helping keep menstrual cycles regular. Doctors commonly prescribe it for:

- Irregular bleeding or absence of periods (secondary amenorrhea).
- Luteal phase deficiency (helping with fertility and IVF cycles).
- Endometriosis or other hormone-related menstrual pain.
- Short-term use in some cases of threatened miscarriage to reduce bleeding risk.

It’s widely used in Europe and Asia but may not be available or commonly used everywhere. Your doctor will pick a dose and schedule based on why you need it — don’t copy someone else’s regimen.

Side effects, safety and practical tips

Most people tolerate dydrogesterone well. Common side effects include headaches, breast tenderness, mild nausea, bloating, and mood changes. Serious problems are rare but can include allergic reactions or significant liver issues.

Practical safety steps:

- Always follow your prescriber’s dose and duration. Typical prescriptions vary, so stick to what your clinician says.
- Tell your doctor if you have liver disease, unexplained vaginal bleeding, a history of blood clots, or hormone-sensitive cancers. These conditions can change whether dydrogesterone is safe for you.
- If you’re pregnant or trying to conceive, discuss the reason for using dydrogesterone. It’s sometimes used in early pregnancy, but that decision should come from your provider.
- If you’re breastfeeding, check with your clinician before starting any hormonal drug.

Drug interactions are uncommon but possible. Share a full medication list with your provider, including herbal supplements and over-the-counter products.

Buying tips if you’re ordering online: always use a licensed pharmacy, get a valid prescription, read reviews, and verify the pharmacy’s registration. Avoid shops that offer controlled medicines without any prescription or ones that use unclear labeling.

Need to switch from another progestin or stop treatment? Talk to your doctor first to avoid sudden hormone changes. If you notice severe side effects, new heavy bleeding, or signs of an allergic reaction (rash, swelling, trouble breathing), get medical help right away.

Questions are normal — ask your prescriber about side effects you worry about, how long you’ll need treatment, and what to expect from follow-up checks. With clear guidance and a reputable pharmacy, dydrogesterone can be a useful option for several hormone-related issues.